Calcitriol: Informations of Calcitriol

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Calcitriol is also famous as bioactive vitamin D is a steroid hormone playing important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. The receptors for vitamin D are present in a wide variety of cells, and that this hormone has biologic effects other than mineral metabolism. Vitamin D3, also known as cholecalciferol is generated in the skin of animals when light energy is absorbed by a precursor molecule 7-dehydrocholesterol.Vitamin D, as either D3 or D2, does not have significant biological activity. It must be metabolized within the body to the hormonally-active form known as 1,25-dihydroxycholecalciferol.

Calcitriol is available as a capsule, an oral liquid, and as an injection. It is generally very well tolerated. The primary side effect is too much calcium in the blood, called hypocalcaemia, which can be prevented with close monitoring of blood calcium levels. Common signs of hypocalcaemia include nausea and vomiting, constipation, drowsiness, decreased reflexes, weakness, increased urination, loss of appetite, and weight loss. Calcitriol increases levels of calcium in the blood in three different ways. The most important is increasing dietary calcium absorption from the small intestines. Calcitriol cannot be given to

patients with elevated serum calcium levels and monitoring is necessary to make sure serum calcium levels do not rise. Calictriol cannot be used in patients that have an elevated (greater than 6 mg/dl) plasma phosphorus level. Calicitriol might elevate phosphorus further at this stage which is exactly what we do not want.