Calcitriol: June 2012

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Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. Low blood levels of calcium may cause bone disease. There are differents precautions :

General : Excessive dosage of Calcitriol Injection induces hypocalcaemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium and phosphorus should be determined at least twice weekly. Should hypocalcaemia develop, the drug should be discontinued immediately. Calcitriol Injection should be given cautiously to patients on digitalis, because hypocalcaemia in such patients may precipitate cardiac arrhythmias.

Information for the Patient : The patient and his or her parents should be informed about adherence to instructions about diet and calcium supplementation and avoidance of the use of unapproved non-prescription drugs, including magnesium-containing antacids.

Essential Laboratory Tests: Serum calcium, phosphorus, magnesium and alkaline phosphatase and 24-hour urinary calcium and phosphorus should be determined periodically. During the initial phase of the medication, serum calcium and phosphorus should be determined more frequently (twice weekly).

Drug Interactions: Magnesium-containing antacid and Calcitriol Injection should not be used concomitantly, because such use may lead to the development of hypermagnesemia.

Pregnancy: Teratogenic Effects: Calcitriol has been found to be teratogenic in rabbits when given orally at doses of 0.08 and 0.3 mcg/kg. Teratogenicity studies in rats at doses up to 0.45 mcg/kg orally showed no evidence of teratogenic potential. There are no adequate and well-controlled studies in pregnant women.

Nursing Mothers : It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from calcitriol, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use : Pediatric use information is approved for Abbott Laboratories' calcitriol injection. However, due to Abbott Laboratories' marketing exclusivity rights, this drug product is not labeled for pediatric use.

Welcome all of you, We deals in complete pharmacy products such like as Calcitriol , Rabeprazole with Domperidone, Ferrous Ascorbate, Acelofenac and Paracetamol with Serrrtiopeptidase , Tramadol with Paracetamol , Amoxicillin and Clavulanate Potassium, Pregabalin with Methylcobalamin , Clindamycin Capsule and Injection, Moxifloxacin, MXF-400, Deflazacort, Vitamin D3 Injection, Cefpodoxime Dry Syrup Focal D3 Injection.

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Welcome To Plenus Pharmaceuticals (P) Ltd

Calcitriol, or 1,25-dihydroxycholecalciferol, is the active form of vitamin D found in the body used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands are not working normally. Low blood levels of calcium cause bone thinning. Calcitriol works by helping the body to use more of the calcium found in foods or supplements. Calcitriol increases the absorption of calcium from the gastrointestinal tract. Calcitriol provides the strengthening of the bones and teeth by organizing the absorption of phosphor and calcium. It prevents rickets. For that reason, it is necessary for the children in growing age. It is good for digestion system, provides good functioning for the intestines. It has benefits for muscles, skin and pancreas. Normally people's bodies whose get necessary sun light produce needed. In addition to this, in newborns, in children that are in growing age and in women who are in nursing period, it should be taken much more from outside with the foods. The main source of vitamin D is fish meat, milk and egg yolk.

Calcitriol mediates its biological effects by binding to the vitamin D receptor, which is principally located in the nuclei of target cells. The binding of calcitriol to the VDR allows the VDR to act as a transcription factor that modulates the gene expression of transport proteins, which are involved in calcium absorption in the intestine. The last step: Calcitriol is hydroxylated again, this time by enzymes in our kidneys (and other body tissues) to the active form of vitamin D, calcitriol also known as 1,25-di-hydroxy-cholecalciferol, or 1,25(OH)2D. Vitamin D is the name given to a vitally important group of micro-nutrients which includes vitamin D3 .