Tuesday, 24 July 2012

Uses of Calcitriol


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Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcitriol is used to treat overactive parathyroid glands and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis. Calcitriol is also used to treat calcium deficiency and metabolic bone disease in people who are receiving dialysis. Calcitriol is also used to treat calcium deficiency in people with hyperparathyroidism caused by surgery, disease, or other conditions. Calcitriol is usually used along with specific diet recommendations and sometimes other medications.

Calcitriol, also known as the prescription drug Rocaltrol, is a synthetic drug that is part of the vitamin D family. This drug is specifically labeled as vitamin D3. It helps to absorb calcium in the stomach for use within the body. This drug is used by people who have calcium deficiencies caused by hyperparathyroidism and bone disorders caused by kidney failure. Calcitriol is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products. Vitamin D helps control parathyroid hormone and the levels of certain minerals that are needed for building and keeping strong bones. Calcitriol is used in patients with kidney disease who can't make enough of the active form of Vitamin D.


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Friday, 13 July 2012

Informations of Calcitriol


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Plenus Pharmaceuticals is built on its meaning of completeness in pharmaceutical field through our quality healthcare service that leads to healthy life everywhere. It is complete healthcare in every aspect where there is no compromise with quality of products, ensuring full satisfaction to concerned entities.

Calcitriol is also famous as bioactive vitamin D is a steroid hormone playing important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. The receptors for vitamin D are present in a wide variety of cells, and that this hormone has biologic effects other than mineral metabolism. Vitamin D3, also known as cholecalciferol is generated in the skin of animals when light energy is absorbed by a precursor molecule 7-dehydrocholesterol.Vitamin D, as either D3 or D2, does not have significant biological activity. It must be metabolized within the body to the hormonally-active form known as 1,25-dihydroxycholecalciferol.

Calcitriol is available as a capsule, an oral liquid, and as an injection. It is generally very well tolerated. The primary side effect is too much calcium in the blood, called hypocalcaemia, which can be prevented with close monitoring of blood calcium levels. Common signs of hypocalcaemia include nausea and vomiting, constipation, drowsiness, decreased reflexes, weakness, increased urination, loss of appetite, and weight loss. Calcitriol increases levels of calcium in the blood in three different ways. The most important is increasing dietary calcium absorption from the small intestines. Calcitriol cannot be given to
patients with elevated serum calcium levels and monitoring is necessary to make sure serum calcium levels do not rise. Calictriol cannot be used in patients that have an elevated (greater than 6 mg/dl) plasma phosphorus level. Calicitriol might elevate phosphorus further at this stage which is exactly what we do not want.


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Saturday, 23 June 2012

Precautions of Calcitriol


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Calcitriol

 Plenus Pharmaceuticals is built on its meaning of completeness in pharmaceutical field through our quality healthcare service that leads to healthy life everywhere. It is complete healthcare in every aspect where there is no compromise with quality of products, ensuring full satisfaction to concerned entities.

Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. Low blood levels of calcium may cause bone disease. There are differents precautions :

General : Excessive dosage of Calcitriol Injection induces hypocalcaemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium and phosphorus should be determined at least twice weekly. Should hypocalcaemia develop, the drug should be discontinued immediately. Calcitriol Injection should be given cautiously to patients on digitalis, because hypocalcaemia in such patients may precipitate cardiac arrhythmias.

Information for the Patient : The patient and his or her parents should be informed about adherence to instructions about diet and calcium supplementation and avoidance of the use of unapproved non-prescription drugs, including magnesium-containing antacids.

Essential Laboratory Tests: Serum calcium, phosphorus, magnesium and alkaline phosphatase and 24-hour urinary calcium and phosphorus should be determined periodically. During the initial phase of the medication, serum calcium and phosphorus should be determined more frequently (twice weekly).

Drug Interactions: Magnesium-containing antacid and Calcitriol Injection should not be used concomitantly, because such use may lead to the development of hypermagnesemia.

Pregnancy: Teratogenic Effects: Calcitriol has been found to be teratogenic in rabbits when given orally at doses of 0.08 and 0.3 mcg/kg. Teratogenicity studies in rats at doses up to 0.45 mcg/kg orally showed no evidence of teratogenic potential. There are no adequate and well-controlled studies in pregnant women.

Nursing Mothers : It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from calcitriol, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use : Pediatric use information is approved for Abbott Laboratories' calcitriol injection. However, due to Abbott Laboratories' marketing exclusivity rights, this drug product is not labeled for pediatric use.


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Friday, 15 June 2012

Benifits of Calcitriol


Welcome To Plenus Pharmaceuticals (P) Ltd
Plenus Pharmaceuticals is built on its meaning of completeness in pharmaceutical field through our quality healthcare service that leads to healthy life everywhere. It is complete healthcare in every aspect where there is no compromise with quality of products, ensuring full satisfaction to concerned entities.

Calcitriol, or 1,25-dihydroxycholecalciferol, is the active form of vitamin D found in the body used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands are not working normally. Low blood levels of calcium cause bone thinning. Calcitriol works by helping the body to use more of the calcium found in foods or supplements. Calcitriol increases the absorption of calcium from the gastrointestinal tract. Calcitriol provides the strengthening of the bones and teeth by organizing the absorption of phosphor and calcium. It prevents rickets. For that reason, it is necessary for the children in growing age. It is good for digestion system, provides good functioning for the intestines. It has benefits for muscles, skin and pancreas. Normally people's bodies whose get necessary sun light produce needed. In addition to this, in newborns, in children that are in growing age and in women who are in nursing period, it should be taken much more from outside with the foods. The main source of vitamin D is fish meat, milk and egg yolk.

Calcitriol mediates its biological effects by binding to the vitamin D receptor, which is principally located in the nuclei of target cells. The binding of calcitriol to the VDR allows the VDR to act as a transcription factor that modulates the gene expression of transport proteins, which are involved in calcium absorption in the intestine. The last step: Calcitriol is hydroxylated again, this time by enzymes in our kidneys (and other body tissues) to the active form of vitamin D, calcitriol also known as 1,25-di-hydroxy-cholecalciferol, or 1,25(OH)2D. Vitamin D is the name given to a vitally important group of micro-nutrients which includes vitamin D3 .


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Plenus Pharmaceuticals Private Limited
PLENUS BUILDING
SHIV VIHAR, NEAR LAL MANDIR,
ARYA NAGAR JWALAPUR,
HARIDWAR. ( U.K.) 249407
Mobile: 09737475726